Comparison of drug release and mechanical properties of tramadol-hydrochloride matrix tablets prepared with selected hydrophilic polymers
نویسندگان
چکیده
منابع مشابه
Formulation of Sustained Release Metformin Hydrochloride Matrix Tablets: Influence of Hydrophilic Polymers on the Release Rate And In Vitro Evaluation
Metformin HCL, the only available biguanide, remains the first line drug therapy for patients with Type 2 diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. It has relatively short plasma half life, low absolute bioavailability. The overall objective of the present work was to develop an oral sustained release metformin tablet prepared by direct compr...
متن کاملdetermination of some physical and mechanical properties red bean
چکیده: در این تحقیق، برخی خواص فیزیکی و مکانیکی لوبیا قرمز به-صورت تابعی از محتوی رطوبت بررسی شد. نتایج نشان داد که رطوبت بر خواص فیزیکی لوبیا قرمز شامل طول، عرض، ضخامت، قطر متوسط هندسی، قطر متوسط حسابی، سطح تصویر شده، حجم، چگالی توده، تخلخل، وزن هزار دانه و زاویه ی استقرار استاتیکی در سطح احتمال 1 درصد اثر معنی داری دارد. به طوری که با افزایش رطوبت از 54/7 به 12 درصد بر پایه خشک طول، عرض، ضخام...
15 صفحه اولIn Vitro Studies of Controlled Release Alfuzosin Matrix Tablets Prepared with Ethylcellulose and Hydroxypropyl Methylcellulose
Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
متن کاملcomparison of hydrophilic natural gums and cellulosic polymers in formulation of sustained-release matrix tablets of terbutalin sulfate
the short half-life of terbutaline sulphate (tbs) requires frequent dosing for controlling chronic pulmanary disorders, such as night asthma. the purpose of the present study was to prepare sustained-release (sr) tablets of tbs to decrease the number of doses frequency and to promote the paitent compliances. it was also desirable to evaluate the capability of natural gums for preparation of sr ...
متن کاملPreparation and Evaluation of Sustained Release Matrix Tablets of Tramadol Hydrochloride Using Glyceryl Palmitostearate
Purpose: To prepare oral sustained release matrix tablets of a highly water soluble drug, tramadol hydrochloride, and to evaluate the effect of concentration of the hydrophobic polymer content and method of preparation on drug release. Methods: The tablets were a mixture of both tramadol hydrochloride and glyceryl palmitostearate (GP) prepared by melt granulation (MG1, MG2, MG3 and MG4 in ratio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Industry and Chemical Engineering Quarterly
سال: 2015
ISSN: 1451-9372,2217-7434
DOI: 10.2298/ciceq140613040n